IgE Allergy vs. Non-IgE Allergy

IgE FOOD ALLERGY: (Typical food allergy) Immediate onset reactions	Non- IgE Food Allergy: (PROTEIN INTOLERANCE) Delayed onset reactions
The body's abnormal immune response to a food, usually a protein.	Mediated by non-IgE antibodies and/or cellular immune responses.
Common Conditions*: 1.     IgE food allergy (ie egg, milk, peanut, tree nut, soy, wheat, shell fish…) 2.     Eosinophilic Disorders 3.     Oral Allergy Syndrome *list is not inclusive, please see your doctor for any symptoms/diagnosis	Common conditions*: 1.     Milk/Soy Protein Intolerance 2.     Multiple Food Protein Intolerance 3.     Food protein-Induced Allergic Protocolitis 4.     Food Protein Induced Enterocolitis Syndrome 5.     Food Protein Enteropathy 6.     Celiac Disease (also auto-immune) 7.     Eosinophilic Disorders (also IgE) *list is not inclusive, please see your doctor for any symptoms/diagnosis
Common Respiratory Symptoms: ·          Sneezing, runny nose, congestion, hay fever ·          Shortness of breath ·          Throat swelling ·          Cough ·          Allergic asthma ·          Pink eye/eye swelling	Common Respiratory Symptoms: ·          Non-allergic sneezing, congestion, runny nose ·          Non-atopic cough, asthma ·          Recurrent or chronic sinus inflammation/infections ·          Reflux disease ·          Recurrent ear infections ·          Eye swelling ·          Enlarged adenoids
COMMON GI SYMPTOMS: Nausea/Vomiting/Diarrhea Cramping abdominal pain Reflux/Difficulty swallowing Swelling (tongue,lips,face) Itching/swelling of the tongue, lips, mouth Dizziness Fainting Severe reactions (anaphylaxis) can be life threatening and require immediate medical attention and can include: Itching or tightness in the throat Difficulty breathing Wheezing/coughing Rapid heart rate Low blood pressure Loss of consciousness Symptoms usually occur within minutes to 1-2 hours after ingesting the food.	COMMON GI SYMPTOMS for MSPI/MFPI: Mucus/Blood in Stools Inconsolable and Extended Crying/Colic Disrupted Sleep Malabsorption/Vitamin Deficiency "Spit-up" an hour+ after feeding Sulfur/sour smelling stools Diarrhea and/or constipation Red ring around the anus Peeling diaper rash Gas/wind Mouth itching Dysbiosis Symptoms can occur hours to days after ingesting the food. COMMON SYMPTOMS for FPIES will include above and: Loss of appetite Violent/forceful/projectile vomiting Lethargy Dehydration Low body temp or fever Low blood pressure Shock Click here for more information on: Celiac, Eosinophilic disorders
Common skin symptoms: ·          Eczema ·          Hives ·          Rashes (dermatitis)	Common skin symptoms: ·          Eczema ·          Rashes/flushing ·          Itchy skin ·          Diaper rash.
Diagnostic Tests: ·          RAST (serum IgE) ·          Skin Prick Testing ·          EE requires endoscopy	Diagnostic Tests: ·          Atopy Patch Testing ·          Food elimination and challenge ·          Endoscopy/colonoscopy ·          Medical history

References:

Non-IgE food Allergy by Dr.Jyonouchi http://www.pcrcd.org/Jyonouchi_IA-DT.pdf 

2010 Guidelines for Diagnosis and Management of Food Allergy in the United States  http://www.niaid.nih.gov/topics/foodallergy/clinical/Pages/default.aspx

Protein Intolerances  http://emedicine.medscape.com/article/931548-overview